This Week in Science

In Science this week, a group led by researchers from the University of Zurich publish high-resolution crystal structures of two major subtypes of Cas9 enzymes, the nucleases responsible for the double-strand DNA breaks that occur with CRISPR-based gene editing. The work provides new insights into how Cas9 interacts with guide RNA to determine target DNA binding, and may give other researchers clues on how to better engineer CRISPR systems for gene editing.

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