This Week in Science

In Science Translational Medicine this week, a team from Northwestern University reports on the use of a novel nanoparticles to deliver therapeutic RNAi agents into brain tumors in mice. Called spherical nucleic acids, the nanoparticles are essentially gold cores surrounded by a dense shell of highly oriented DNA or RNA. In the study, the researchers were able to use SNAs to carry siRNAs against a key oncogene into tumors in mouse models, where they knocked down their target and killed off cancer cells.

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With a new collection, PLOS highlights negative results it has published.