This Week in Science

In Science this week, a team led by Stanford University researchers report the architecture of a complete, 32-protein, RNA polymerase II transcription pre-initiation complex. The structure was determined using cryo-EM and a combination of chemical cross-linking and mass spectrometry, and showed a "marked division" in two parts — one containing all the general transcription factors and the other pol II.

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In Science this week: mtDNA analysis give glimpse into decline of Neanderthals in Europe, and more.

The University of Arizona's Raina Maier writes that an understanding of the Earth's microbiome is needed.

The proposed Canadian budget emphasizes partnerships with industry, Nature News reports.

An Australian study of personalized medicine has run into problems as it recruits patients.