This Week in Science

In Science this week, a multi-institute team of Japanese researchers report new details on the role of epigenetics in sex determination, finding that histone demethylation influences whether an embryo will be male or female. Specifically, the protein Jmjd1a was discovered to control the demethylation of a sex-determining gene called Sry in mice. Loss of Jmjd1a function in developing animals resulted in the reversal of their sex from male to female.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.