This Week in Science

In this week's Science, Baylor College of Medicine researcher James Lupski offers his thoughts on genome mosaicism and its implications for human health. Amid advances in sequencing technology, it is becoming apparent that individual humans are made up of a population of cells, each with its own "personal" genome, he says. This mosaicism may turn out to be more widespread than previously anticipated, raising questions as to the extent of its influence on development and disease.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.