This Week's Science

In Science this week, researchers from McGill University reported new details about the activation of Parkin, a gene that, when mutated, is responsible for an autosomal recessive form of Parkinson’s disease. Using x-ray scattering, the team determined the crystal structure of the full-length parkin protein in rat tissue. The protein is ordinarily inactive, but they found that mutations that the disrupted two inhibitory binding interactions activated it.

Get the full story

This story is free
for registered users

Registering provides access to this and other free content.

Register now.

Already have an account?
Login Now.

Related Posts

This Week in PNAS

This Week in Nature

This Week in PNAS

This Week in PNAS

This Week in Cell

This Week in PLOS

In PNAS this week: Akt3 amplification in glioma progression, Tibetan Plateau frog genome, and more.

The US Supreme Court has declined to review a decision involving the use of "inadvertently shed" DNA in a police investigation and subsequent conviction.

A panel at the New York Times discusses anonymity and privacy of users of 23andMe's services when access to its database is offered for research.

National Institutes of Health Director Francis Collins appears before a House subcommittee to discuss his agency's budget request.