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This Week in Science: Apr 5, 2013

In Science this week, researchers from the University of Massachusetts and the University of Oxford report on the discovery that transposons are more mobile in certain neurons than others in the Drosophila brain. Fly cells typically use the piwi-interacting proteins Aubergine and Argonaute 3 to suppress transposable elements. However, in mushroom body neurons, where transposon expression is more abundant, these two proteins are less abundant. The team suggests that the greater level of transposons in this part of the brain helps ensure genomic heterogeneity.

Also in Science, investigators from the UK's Medical Research Council present a paper indicating that translational inhibition is the primary event required for microRNA-mediated mRNA degradation, and that the process relies on impairing the function of the eIF4F initiation complex. Additionally, the scientists report a "correlation between the presence of miRNA target sites in the 3' untranslated region of mRNAs and secondary structure in the 5' UTR and show that mRNAs with unstructured 5' UTRs are refractory to miRNA repression."

The Scan

WHO OKs Emergency Use of Sinopharm Vaccine

The World Health Organization has granted emergency approval for Sinopharm's SARS-CoV-2 vaccine, the Guardian reports.

Scientific Integrity Panel to Meet

According to the Associated Press, a new US scientific integrity panel is to meet later this week.

Trying in the Eye

NPR reports that a study of Editas Medicine's CRISPR therapy for Leber congenital amaurosis has begun.

PLOS Papers on Cerebellum Epigenetics, Copy Number Signature Tool, Acute Lung Injury Networks

In PLOS this week: epigenetics analysis of brain tissue, bioinformatics tool to find copy number signatures in cancer, and more.