This Week in Science

In Science this week, a Cornell University team reports on the results of a study using a precision nuclear run-on and sequencing assay to map the genome-wide distribution of transcriptionally engaged Pol II at base-pair resolution. They found that Pol II accumulates immediately downstream of promoters, at intron-exon junctions that are efficiently used for splicing and over 3′ polyadenylation sites.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.