This Week in Science

In Science this week, a team led by researchers from the University of Manchester report on the creation of an artificial small-molecule machine capable of creating peptides, moving one step close to the development of a man-made ribosome. The machine, which is based on a rotaxane, travels alone a molecular strand, picking up amino acids placed in its way and synthesizing a peptide in a sequence-specific manner.

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.