This Week in Science

In Science this week, a team led by researchers at the University of Toronto report on the discovery that cancers with identical genomes can sometimes act differently, including how they respond to treatment. Using DNA copy number alteration profiling, sequencing, and lentiviral lineage tracking, the investigators followed the repopulation dynamics of 150 single lentiviral-marked lineages from 10 human colorectal cancers through serial xenograft passages in mice.

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Harold Varmus, the director of the National Cancer Institute, has announced that he is stepping down after nearly five years.