This Week in Science

Genome-wide association studies have indicated that polymorphisms in a stretch of DNA upstream from the MYC oncogene are also related to increased cancer risk. Further, a regulatory element in that region appears to alter MYC expression levels. And so researchers from the Karolinksa Institute in Sweden and the University of Helsinki in Finland developed mice deficient in that regulatory region, Myc-335, to determine its role in Myc expression and tumor formation.

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