Skip to main content
Premium Trial:

Request an Annual Quote

This Week in Science: Oct 26, 2012

In Science this week, researchers from the Braunschweig University of Technology describe the use of a technique of folding DNA at the nanoscale — called DNA origami — to create structures that can be used to visualize biological processes at the single-molecule level. By linking gold nanoparticles to DNA origami structures that incorporate docking sites for a single fluorescent dye, the team created a "nano-lens" that acts as a nanoantenna capable of enhancing the fluorescence. The technique offers a fast and inexpensive alternative to existing single-molecule visualization approaches, the researchers say.

In Science Translational Medicine, an international team led by University of Cambridge researchers report on the combination of imaging and genomic data to better predict the survival of breast cancer patients — since solid tumors are composed of both cancer and normal cells, interpretation of their molecular profiles can be challenging. Additionally, "tissue architecture is generally not reflected in molecular assays, rendering this rich information underused." To tackle these issues, the investigators developed algorithms identify a cell based on the shape of its nucleus and combined those algorithms with gene-expression analyses to create a robust method that could predict survival in estrogen receptor-positive breast cancer patients. This integrated approach helps bridge the gap between visual pathology and quantitative molecular analyses, the team adds.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.