Also in Science, University of North Carolina at Chapel Hill investigators and their colleagues proposed a new scheme by which intestinal inflammation promotes colorectal cancer. In addition to directly altering physiology to facilitate tumor growth, inflammation was shown to modify the microbial composition in colitis-susceptible interleukin-10-deficient mice, reducing the overall number of species while boosting the growth of Escherichia coli. The result is the production of a genotoxin that appears to contribute to cancer independently of inflammation.
Over in Science Translational Medicine, a team led by Massachusetts Institute of Technology researchers detail the development of tumor-penetrating nanocomplexes capable of carrying therapeutic RNAi molecules deep into tumors. The delivery vehicles are comprised of siRNAs targeting the ovarian cancer oncogene ID4 that have been complexed with a tandem tumor-penetrating and membrane-translocating peptide. When delivered to mice, the nanocomplexes entered the tumor parenchyma, the siRNAs silenced their target, significantly suppressing tumor growth.