This Week in Science | GenomeWeb

This Week in Science

Researchers at Genentech report in a paper published online in advance in Science this week that "loss of the tumor suppressor BAP1 causes myeloid transformation." In mouse, Bap1 gene deletion is lethal, the authors write, but "systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelodysplastic syndrome." Further, the Genentech team presents evidence to suggest that BAP1 loss of function has similar consequences in human.

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Harold Varmus, a former NIH director, says that proposed reductions to the agency's budget are worrisome.

The Genome 10K project is to sequence about 10,000 vertebrate genomes, including ones of endangered species, Digital Trends reports.

The new Coalition to Save NIH Funding aims to educate lawmakers and the public on the significance of biomedical research.

In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.