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In a paper published online in advance in Science this week, an international team led by investigators at the University of Cambridge shows that segment 3 of the influenza A virus contains a second open reading frame, X-ORF, which is accessed by way of ribosomal shifting. The team found that the product of this, PA-X, modulates virulence in a mouse model by decreasing pathogenicity.

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The US Centers for Disease Control and Prevention has identified a small group of breakthrough COVID-19 cases, the Wall Street Journal reports.

The New York Times reports that the US Department of Defense is to use genetic genealogy approaches to identify the remains of unknown soldiers.

Vox and Nature discuss the importance of preparing for the next pandemic.

In Nature this week: comparison of five circulating tumor DNA assays, resequencing analysis of lettuce gives insight into its domestication, and more.