This Week in Science

In a report published online in advance in Science this week, University of Cambridge's Eric Miska and his colleagues discuss the roles of piwi-interacting RNAs in Caenorhabditis elegans. "Our data suggest that nematode piRNA clusters are evolving to generate piRNAs against active mobile elements," Miska et al. write. "Thus, piRNAs provide heritable, sequence-specific triggers for RNAi in C. elegans."

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.