This Week in Science

In a report published online in advance in Science this week, University of Cambridge's Eric Miska and his colleagues discuss the roles of piwi-interacting RNAs in Caenorhabditis elegans. "Our data suggest that nematode piRNA clusters are evolving to generate piRNAs against active mobile elements," Miska et al. write. "Thus, piRNAs provide heritable, sequence-specific triggers for RNAi in C. elegans."

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.