Researchers at Case Western Reserve University report in a paper published online in advance in Science this week on their use of "the histone mark H3K4me1 to analyze gain and loss of enhancer activity genome wide in primary colon cancer lines relative to normal colon crypts." Taking this approach, the researchers identified thousands of variant enhancer loci, comprising a signature that they say is "predictive of the in vivo colon cancer transcriptome."

Get the full story

This story is free
for registered users

Registering provides access to this and other free content.

Register now.

Already have an account?
Login Now.

Related Posts

This Week in PLOS

The War Within

This Week in Science

This Week in PNAS

Share Alike

In Science this week: gene linked to expansion of the human neocortex, and more.

The National Institute of General Medical Sciences director says changes the agency made have allow it to boost success rates.

Ancient DNA indicates Stone Age, hunter-gather inhabitants of Britain imported wheat.

Joel Achenbach explores at National Geographic why people find science difficult to believe.