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This Week in Science : Dec 10, 2011

In a paper published online in advance in Science this week, investigators at Baylor College of Medicine show that a subset of SUMOylation-dependent Myc switchers, or SMS genes, "is required for mitotic spindle function and to support the Myc oncogenic program." As a result of its findings, the Baylor team says "inhibition of SUMOylation may merit investigation as a possible therapy for Myc-driven human cancers."

Over in this week's issue, researchers at the University of Missouri show that Arabidopsis EDS1 — "a positive regulator of basal resistance and of effector-triggered immunity specifically mediated by Toll-interleukin-1 receptor-nucleotide binding-leucine-rich repeat) resistance proteins" — forms complexes with RPS4 and RPS6 — TIR-NB-LRR disease resistance proteins — at a cytoplasmic membrane. The authors suggest that the tight association of EDS1 with TIR-NB-LRR–mediated immunity "may directly connect to the basal resistance signaling pathway via EDS1."

Science Signaling this week points to Expression2Kinases, or X2K, as a handy "Java-based application for identifying the proteins and signaling pathways that are likely to be involved in mediating these observed differences in gene expression." X2K integrate protein-protein and kinase-substrate interaction information with data from ChIP experiments, position weight matrices, or both, "to identify the transcription factors that are likely to be involved and the cell signaling components that regulate the activities of these transcription factors," the journal's editors say.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.