In a paper published online in advance in Science this week, investigators at Baylor College of Medicine show that a subset of SUMOylation-dependent Myc switchers, or SMS genes, "is required for mitotic spindle function and to support the Myc oncogenic program." As a result of its findings, the Baylor team says "inhibition of SUMOylation may merit investigation as a possible therapy for Myc-driven human cancers."

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Sometimes genetic tests give inconclusive results and provide little reassurance to patients, the Associated Press reports.

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In Science this week: research regulation and reporting requirement reform, and more.

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