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In Science this week, researchers in the US and Sweden find functional links between beta-amyloid peptide toxicity and risk factors for Alzheimer's disease by modeling Aβ toxicity in yeast. A genome-wide screen for toxicity modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein and other factors connected to Alzheimer's that had not previously been connected to Aβ toxicity.

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A small, early-stage trial of a combination therapy for brain cancer reports favorable responses in two patients, according to the Guardian.

Nature News writes that viral genomic surveillance in the US faces systemic issues.

President Joe Biden is seeking an increase in federal spending, including higher budgets for the National Institutes of Health and Centers for Disease Control and Prevention.

In PLOS this week: sex-stratified genome-wide association study of chronic pain, sequencing data from Indigenous Mexican groups, and more.