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In this week's issue of Science, Miyuki Sato and Ken Sato from Gunma University in Japan report that autophagy is necessary for the removal of the paternal mitochondria genome in C. elegans. "Autophagosomes engulf paternal mitochondria, resulting in their lysosomal degradation during early embryogenesis," Sato and Sato write, adding that that gives rise to the maternal inheritance of mitochondria.

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A small, early-stage trial of a combination therapy for brain cancer reports favorable responses in two patients, according to the Guardian.

Nature News writes that viral genomic surveillance in the US faces systemic issues.

President Joe Biden is seeking an increase in federal spending, including higher budgets for the National Institutes of Health and Centers for Disease Control and Prevention.

In PLOS this week: sex-stratified genome-wide association study of chronic pain, sequencing data from Indigenous Mexican groups, and more.