Researchers at Germany's Institut für Allgemeine Pharmakologie und Toxikologie show in Science Signaling this week that "signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and microRNA-21." The team shows that, "by stimulating pro-inflammatory PDCD4 and decreasing the abundance of miR-21, decorin signaling boosts inflammatory activity in sepsis and suppresses tumor growth."