This Week in Science

In Science this week, a team led by researchers at University of Massachusetts Medical School shows that in the mammalian genome, genome-wide demethylation followed by de novo methylation initiates "a pattern inherited throughout development and modified only at tissue-specific loci." The UMass Med-led team reports on its in vivo investigation of methylation in differentiating mouse erythroblasts using reduced representation bisulfite sequencing.

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Germany's Project DEAL has come to an agreement with the publisher Wiley over journal access and open-access publishing, ScienceInsider reports.

A Canadian panel recommends public coverage of the gene therapy Kymriah if its cost comes down, the Globe and Mail reports.

Researchers uncover additional loci associated with lifespan, which the Telegraph says could be folded into a genetic test.

In Nucleic Acids Research this week: new accurate quantification by sequencing approach, CNV breakpoints in Plasmodium falciparum, and more.