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In Science this week, a team led by researchers at University of Massachusetts Medical School shows that in the mammalian genome, genome-wide demethylation followed by de novo methylation initiates "a pattern inherited throughout development and modified only at tissue-specific loci." The UMass Med-led team reports on its in vivo investigation of methylation in differentiating mouse erythroblasts using reduced representation bisulfite sequencing.

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In Science this week: gene expression signature linked to nonalcoholic fatty liver disease progression, and more.