In a paper published online in advance in Science this week, investigators at Finland's University of Helsinki and elsewhere report their identification of tumor-specific mutations in the mediator complex subunit 12 (MED12) gene in 10 of 18 uterine leiomyomas they studied using an exome sequencing approach. The team also reports its analysis of 207 additional tumors, of which 70 percent showed alterations in MED12.