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In a paper published online in advance in Science this week, a team led by investigators at the Broad Institute reports its analysis of whole-exome sequencing data from 74 head and neck squamous cell carcinoma tumor-normal pairs. The team found that more than 30 percent of the cases "harbored mutations in genes that regulate squamous differentiation, implicating its dysregulation as a major driver of HNSCC carcinogenesis."

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A small, early-stage trial of a combination therapy for brain cancer reports favorable responses in two patients, according to the Guardian.

Nature News writes that viral genomic surveillance in the US faces systemic issues.

President Joe Biden is seeking an increase in federal spending, including higher budgets for the National Institutes of Health and Centers for Disease Control and Prevention.

In PLOS this week: sex-stratified genome-wide association study of chronic pain, sequencing data from Indigenous Mexican groups, and more.