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In this week's Science, Harvard University's George Church and his colleagues "present genome engineering technologies that are capable of fundamentally reengineering genomes from the nucleotide to the megabase scale." Called multiplex automated genome engineering and conjugative assembly genome engineering, or MAGE and CAGE, Church et al.'s methods "treat the chromosome as both an editable and an evolvable template, permitting the exploration of vast genetic landscapes," they write.

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The US has sent its formal notice of withdrawal from the World Health Organization, according to the Wall Street Journal.

Science reports that a draft spending bill would increase the US National Institutes of Health budget by 13 percent.

The Harvard Crimson reports that Harvard and MIT are suing the Department of Homeland Security and ICE over the new international student visa policy.

In Nucleic Acids Research this week: algorithm to determine molecular sequence types and other microbial features, computational method to uncover R-loop structures, and more.