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In this week's Science, Harvard University's George Church and his colleagues "present genome engineering technologies that are capable of fundamentally reengineering genomes from the nucleotide to the megabase scale." Called multiplex automated genome engineering and conjugative assembly genome engineering, or MAGE and CAGE, Church et al.'s methods "treat the chromosome as both an editable and an evolvable template, permitting the exploration of vast genetic landscapes," they write.

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This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.