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In Science Signaling this week, researchers in Utah say that HIF-1α mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression. Numerous studies have shown that HIF-1α is over-expressed in many human cancers and up-regulates several hypoxia-responsive genes for cancer growth and survival, the authors write.

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Imperial College London researchers are shifting away from testing a COVID-19 vaccine to focus on combating newly emerging SARS-CoV-2 variants, the Independent says.

According to the Associated Press, genetic genealogy has helped law enforcement officials identify an unknown victim of the Green River Killer.

In PNAS this week: target to reduce chemotherapy-induced cardiac injury, tool finds ancient endogenous RNA viruses, and more.

Moderna reports its vaccine is effective against new SARS-CoV-2 strains, though it is also developing a booster, according to the New York Times.