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In Science Signaling this week, researchers in Utah say that HIF-1α mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression. Numerous studies have shown that HIF-1α is over-expressed in many human cancers and up-regulates several hypoxia-responsive genes for cancer growth and survival, the authors write.

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UK Royal Statistical Society is organizing a working group to develop guidelines for assessing COVID-19 tests, the Guardian reports.

The Washington Post reports that the White House chief of staff has asked the US Food and Drug Administration to justify the stricter standards it is seeking for a coronavirus vaccine.

President Donald Trump's "good genes" comment raises eugenics concerns, CNN reports.

In PLOS this week: genetic analysis of tremor condition, analysis of a West and Central African tree used in traditional medicine, and more.