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In Science this week, a team led by investigators at the University of Massachusetts Medical School reports its use of yeast genetic engineering, chemical biology techniques, and multi-wavelength fluorescence microscopy to "follow assembly of single spliceosomes in real time in whole-cell extracts." In its investigations, the team found that spliceosomal subcomplexes sequentially associate with pre-mRNA, such that they produce functional spliceosomes and that each subcomplex is reversible.

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Researchers are developing a breath test to determine how severe patients' methylmalonic acidemia disease is, FierceBiotech reports.

NPR reports that vaccine developers are working on SARS-CoV-2 vaccines that are easier to store or administer than the current crop.

Reuters reports that France is to recommend that people under 55 who received one dose of AstraZeneca's SARS-CoV-2 vaccine receive a different vaccine for their second dose.