This Week in Science | GenomeWeb

This Week in Science

As an expansion of a CGG repeat in the 5'-UTR of the fragile X mental retardation 1 gene leads to the up-regulation of metabotropic glutamate receptor 5-mediated signaling, an international research team sought to determine "whether a receptor subtype-selective inhibitor of mGluR5, AFQ056, improves the behavioral symptoms of FXS in a randomized, double-blind, two-treatment, two-period, crossover study of 30 male FXS patients aged 18 to 35 years." In Science Translational Medicine this week, the team reports that "seven patients with full FMR1 promoter methylation and no detectable

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Harold Varmus, a former NIH director, says that proposed reductions to the agency's budget are worrisome.

The Genome 10K project is to sequence about 10,000 vertebrate genomes, including ones of endangered species, Digital Trends reports.

The new Coalition to Save NIH Funding aims to educate lawmakers and the public on the significance of biomedical research.

In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.