This Week in Science

In a Science paper published online in advance this week, researchers in China show that loss-of-function mutations in PSENEN, PSEN1, or NCSTN — which encode components of the γ-secretase multiprotein complex — are associated with hidradenitis suppurativa, commonly known as familial acne inversa. The team found these independent mutations in their screen of six Chinese families with features of acne inversa and related clinical sympotoms.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.