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This Week in Science: Jul 9, 2010

In this week's issue of Science, research led by investigators at the Department of Energy's Joint Genome Institute examines the organismal complexity of the multicellular green alga Volvox carteri. Simon Prochnik et al. sequenced the Volvox genome to 11.1-fold coverage using a whole-genome shotgun approach; when compared to Chlamydomonas reinhardtii, its unicellular relative, the team found that "the two species have similar protein-coding potentials and few species-specific protein-coding gene predictions." The authors suggest that "increases in organismal complexity can be associated with modifications of lineage-specific proteins rather than large-scale invention of protein-coding capacity."

In an accompanying news piece, Elizabeth Pennisi writes that "comparison between the genomes of the 2000-cell Volvox carteri and a single-celled green alga, Chlamydomonas reinhardtii, has revealed surprisingly few differences in their gene makeup." Additional research teams have shown similar results. Nicole King at the University of California, Berkeley, and her colleagues demonstrated that the genomes of a single-celled choanoflagellate and several animals were similar. King et al. concluded that "that part of the tree of life arose not so much from new genes but from a shuffling and recombining of existing genes and parts of genes," Pennisi writes.

A paper published online in advance this week, detailing the work of Stanford University researchers and their colleagues, shows that the lincRNA HOTAIR acts as a modular scaffold "for at least two distinct histone modification complexes." Specifically, the team writes, HOTAIR tethers PRC2 and the LSD1/CoREST/REST complex, allowing for the "RNA-mediated assembly of PRC2 and LSD1 to chromatin for coupled histone H3 lysine 27 methylation and lysine 4 demethylation."

In another research article published online in advance, Christopher Gregg and his colleagues at Harvard University and Illumina report their "high-resolution analysis of parent-of-origin allelic expression in the mouse brain." By characterizing genome-wide imprinting in the mouse embryonic and adult brains, the team found "a preferential maternal contribution to gene expression in the developing brain and a major paternal contribution in the adult brain." In a related report, Gregg et al. write that "parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease."

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.