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In an advance, online publication of Science this week, Chaolin Zhang and colleagues at The Rockefeller University report their approach for "understanding mammalian RNA regulation at the systems level" using "Bayesian networks to probabilistically model diverse datasets and predict the target networks of specific regulators." Zhang et al. used their strategy to elucidate nearly 700 alternative splicing events that are directly regulated by Nova, a neuron-specific factor in the mouse brain.

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A small, early-stage trial of a combination therapy for brain cancer reports favorable responses in two patients, according to the Guardian.

Nature News writes that viral genomic surveillance in the US faces systemic issues.

President Joe Biden is seeking an increase in federal spending, including higher budgets for the National Institutes of Health and Centers for Disease Control and Prevention.

In PLOS this week: sex-stratified genome-wide association study of chronic pain, sequencing data from Indigenous Mexican groups, and more.