This Week in Science

In an advance, online publication of Science this week, Chaolin Zhang and colleagues at The Rockefeller University report their approach for "understanding mammalian RNA regulation at the systems level" using "Bayesian networks to probabilistically model diverse datasets and predict the target networks of specific regulators." Zhang et al. used their strategy to elucidate nearly 700 alternative splicing events that are directly regulated by Nova, a neuron-specific factor in the mouse brain.

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The Wall Street Journal reports Human Longevity's valuation has dropped by 80 percent.

The New York Times and ProPublica say that many physicians fail to disclose their financial ties when publishing in medical journals.

Science reports that the US National Cancer Institute is cutting its operating budget by 5 percent.

In PLOS this week: similar variants seen in bullbogs, people with Robinow syndrome; ApoE genotypes in African-American, Puerto Rican populations; and more.