In an advance, online publication of Science this week, investigators at the MRC Laboratory of Molecular Biology in Cambridge, UK, and their colleagues report that the "disruption of both FANCC and [nonhomologous end joining factor] Ku70 suppresses sensitivity to cross-linking agents, diminishes chromosome breaks, and reverses defective homologous recombination" in Fanconi anemia. In this study, the authors demonstrate a function "for the FA pathway in processing DNA ends, diverting double-strand break repair away from abortive NHEJ and toward homologous recombination."
Another study published online, in advance, in Science presents the results of a Wellcome Trust Sanger Institute-led team's investigation of T cells that are reprogrammed to become natural killer-like cells. The team shows that with the deletion of a transcription factor, Bcl11b, "T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell–associated gene expression." The induced T-to-natural-killer, or ITNK cells, are genetically similar to convential NK cells, the team writes, although they "killed tumor cells in vitro and effectively prevented tumor metastasis in vivo."
Researchers at the Institute of Cancer Research in the UK report that "gatekeeper mutations mediate resistance to BRAF-targeted therapies," in Science Translational Medicine this week. By mutating the gatekeeper residue, the team generated drug-resistant versions of oncogenic BRAF. "Signaling by the mutant proteins was resistant to the small-molecule inhibitor sorafenib, but sorafenib still inhibited the growth of tumors driven by the mutant protein," the authors write.
In a news piece in Science this week, Michael Balter discusses the identity debate about Jewish origins, which was initiated by studies published in Nature and the American Journal of Human Genetics this week. Balter quotes two investigators with opposing viewpoints on the studies' results: Shlomo Sand, of Tel Aviv University, says that "the whole concept of identifying Jews genetically is fallacious," while the school's Anita Shapira saya that "it is nice to get support from modern genetics, which refutes [Sand's] assertions."