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In an advance, online publication of Science this week, two reports highlight the role of miR-33 in human cholesterol homeostasis. Katey Rayner and her colleagues at the New York University School of Medicine show that miR-33 "modulates the expression of genes involved in cellular cholesterol transport," adding that silencing miR-33 in vivo increases plasma HDL levels. "miR-33 appears to regulate HDL biogenesis in the liver and cellular cholesterol efflux," Rayner et al. conclude.

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Researchers are developing a breath test to determine how severe patients' methylmalonic acidemia disease is, FierceBiotech reports.

NPR reports that vaccine developers are working on SARS-CoV-2 vaccines that are easier to store or administer than the current crop.

Reuters reports that France is to recommend that people under 55 who received one dose of AstraZeneca's SARS-CoV-2 vaccine receive a different vaccine for their second dose.