This Week in Science

In Science Signaling this week, researchers in Germany report on their loss-of-function RNAi screen which revealed Ras- and Raf-independent MEK-ERK signaling in human epithelial cells during Chlamydia trachmatis infection. Their study also identified 59 host factors that either positively or negatively influenceChlamydia replication; depletion of Ras or Raf in HeLa cells increased the pathogen's growth.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.