This Week in Science | GenomeWeb

This Week in Science

Tsz-Leung To and Narendra Maheshri at MIT describe positive-feedback loops in gene regulatory networks which may exhibit bimodal responses in Science this week. Using a synthetic system in budding yeast, To and Maheshri show that “a promoter with multiple transcription factor binding sites can induce a steady-state bimodal response without cooperative binding of the TF.” The researcher’s deterministic models did not predict bistability, however, which is a finding contrary to common thought.

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In Science this week: metagenomic-based technique for determining protein structure, and more.

An academic laments the rise of narcissism in the sciences, the Guardian reports.

Outgoing FDA commissioner Robert Califf writes in an editorial that the agency can help boost innovation.

The Trump transition team has asked NIH Director Francis Collins to remain at his post, though it's unclear for how long that will be.