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Tsz-Leung To and Narendra Maheshri at MIT describe positive-feedback loops in gene regulatory networks which may exhibit bimodal responses in Science this week. Using a synthetic system in budding yeast, To and Maheshri show that “a promoter with multiple transcription factor binding sites can induce a steady-state bimodal response without cooperative binding of the TF.” The researcher’s deterministic models did not predict bistability, however, which is a finding contrary to common thought.

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The UK has given emergency authorization for Pfizer and BioNTech's SARS-CoV-2 vaccine, the Associated Press reports.

A US advisory committee says healthcare workers and nursing home residents should be prioritized to receive a SARS-CoV-2 vaccine, according to the Financial Times.

The Wall Street Journal reports North Korean hackers have targeted half a dozen companies developing SARS-CoV-2 vaccines.

In Cell this week: long-term SARS-CoV-2 shedding, examination of the effects of a coronavirus spike protein mutation, and more.