This week's Science is no stranger to systems biology. Stanford's Rick Myers and Caltech's Barbara Wold developed a large-scale chromatin immunoprecipitation assay (ChIPSeq) based on direct ultrahigh-throughput DNA sequencing to map, in vivo, all the binding sites (1946 total) of a transcription factor known as neuron-restrictive silencer factor (NSRF).
Another paper describes a technique called PMAGE, or "polony multiplex analysis of gene expression." Researchers at Harvard used PMAGE to detect levels of mRNA as little as one transcript per three cells, allowing them to detect the early transcriptional signs of hypertrophic cardiomyopathy in mice carrying a mutation that causes the disease.
Two studies conducted by an international team of geneticists and cardiologists used genome-wide association studies to show that about 25% of Caucasians carry a risk gene on chromosome 9 that makes them up to 40% more susceptible to various forms of heart disease.
Finally, Michael Behe is back with a slightly revised version of his theory of intelligent design. A book review criticizes the content of Behe's new book, The Edge of Evolution: The Search for the Limits of Darwinism, arguing that it’s based on faulty science.