In Science this week, researchers describe their determination that N-terminally (Nt) acetylated Met residue could act as a degradation signal (degron), targeted by the Doa10 ubiquitin ligase, in the yeast Saccharomyces cerevisiae. They also show that Doa10 also recognized the Nt-acetylated alanaine, valine, serine, threonine, and cysteine residues.