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This Week in Science: May 25, 2007

Today's Science has a special feature on advances in single-molecule techniques. This portal includes papers on protein counting, transcription factor binding, and understanding the dynamics of single molecules, as well as several reviews of relevant efforts in the space. Among the technologies highlighted are NMR, X-ray crystallography, microfluidics, and computational work.

Another prime focus in the current issue is on DNA damage and cellular response. Following a review by John Petrini from Memorial Sloan-Kettering Cancer Center, four papers home in on different aspects of DNA damage:

  • Lead author Shuhei Matsuoka from Brigham and Women's Hospital reports on a large-scale analysis of phosphorylated proteins in response to DNA damage, finding more than 900 phosphorylation sites implicating at least 700 proteins.
  • Bin Wang, also at Brigham and Women's, is the lead author on a paper demonstrating proteins that bind into a complex that is required for DNA damage response linked to breast and ovarian cancer.
  • Dana-Farber's Bijan Sobhian is lead author on another paper focusing on the interaction of a particular breast cancer tumor suppressor with a ubiquitin-binding protein.
  • Finally, Hongtae Kim at Yale is first author on a paper that also focuses on RAP80 and its role in the breast cancer-associated damage response.

 

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.