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In Science this week, researchers show that a phospholipid that binds to nuclear enzymes modifies gene transcription in response to external stimuli. Sarah Spiegel at Virginia Commonwealth University is the senior author on work that found that the lipid sphingosine-1-phosphate can also bind to histone deacetylases 1 and 2. The enzyme that creates S1P, sphingosine kinase 2, is present in the nucleus in complexes with HDAC1 and HDAC2.

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Novavax has begun a phase III trial of its SARS-CoV-2 vaccine, according to the New York Times.

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This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.