In early online publication this week, Stefanie Dimmeler at Goethe-University Frankfurt showed that a specific miRNA controls angiogenesis in mice. In the work, she and her team found that the miR-17~92 cluster is highly expressed in human endothelial cells and that one in particular, miR-92a, controls angiogenesis. When they overexpressed miR-92a in endothelial cells, it blocked angiogenesis both in vitro and in vivo.