This Week in PNAS

In the PNAS Early Edition this week, a trio of investigators at the National Institute of Environmental Health Sciences reports the crystal structure of a human DNA polymerase λ variant, which they say forms "a natural base-base mismatch with Watson-Crick-like geometry." This variant, the authors write, is "poised to misinsert dGTP opposite a template T," such that the resulting mismatch "has Watson-Crick geometry consistent with a tautomeric or ionized base pair, with the pH depende

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Oxford Nanopore Technologies is looking into dual listings in London and Hong Kong, according to the South China Morning Post.

The New York Times looks into medical research funding in the US and how the grant system might not be funding the best work.

US lawmakers proposed increasing the National Science Foundation budget, including its facilities account, Science reports.

In PNAS this week: effects of gene deletions on bacterial metabolic networks, genetic responses to sea star wasting disease, and more.