This Week in PNAS

In the PNAS Early Edition this week, a trio of investigators at the National Institute of Environmental Health Sciences reports the crystal structure of a human DNA polymerase λ variant, which they say forms "a natural base-base mismatch with Watson-Crick-like geometry." This variant, the authors write, is "poised to misinsert dGTP opposite a template T," such that the resulting mismatch "has Watson-Crick geometry consistent with a tautomeric or ionized base pair, with the pH depende

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Though many details have yet to be worked out, the draft deal for the UK's withdrawal from the EU is giving researchers some hints for what they can expect, Nature News says.

DNA testing has solved a 100-year-old mystery contained in the skull and teeth samples of a now-extinct monkey that once inhabited Jamaica, Gizmodo reports.

As the UN ponders a ban on gene drives, one malaria researchers says there are less dramatic ways to fight the disease in Africa than unleashing GM mosquitoes on a whole continent.

In Nature this week: an improved reference genome of the Aedes aegypti mosquito, genomes of four species of truffles, and more.