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In this week's PNAS Early Edition, researchers at the Sanford-Burnham Medical Research Institute, along with their collaborators at Columbia University, show that deletion of DDB1 "abrogates the self-renewing capacity of hepatocytes, resulting in compensatory proliferation of DDB1-expressing hepatocytes." In addition, the team shows that "constitutive stimulation of this regeneration process leads to development of hepatocellular carcinoma, which surprisingly contains no disruption of the DDB1 gene." The authors suggest this indicates a "cell-non-autonomous role of DDB1 inactivatio

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A 50-year-old cold case was cracked using genetic genealogy, the New York Times reports.

NPR reports that some insect pests are now becoming resistant to Bt crops.

Science reports the US Food and Drug Administration did not consult an outside panel in its approval of remdesivir as a COVID-19 treatment.

In Nature this week: a framework for future human genomic research, PORE-cupine approach to study RNA structure using nanopore sequencing, and more.