This Week in PNAS

This week, PNAS reports on a new method to study small molecule metabolites in C. elegans, especially how they might interact synergistically. Using a NMR-spectroscopic method, differential analysis by 2D NMR spectroscopy (DANS), they were able to compare wild-type C. elegans and a mutant lacking pheromone signaling genes to identify both known and unknown ascarosides – in variable concentrations, these molecules can be both sex pheromones and developmental regulators.

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A genome-wide association study highlights a potential role for hair follicles in acne risk, according to New Scientist.

Newsday reports that breast cancer genetic testing guidelines for are out of date and may miss individuals.

In Cell this week: gene editing-based strategy to screen for immune system regulators, ancient plague patterns, and more.

Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.