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This Week in PNAS

This week, PNAS reports on a new method to study small molecule metabolites in C. elegans, especially how they might interact synergistically. Using a NMR-spectroscopic method, differential analysis by 2D NMR spectroscopy (DANS), they were able to compare wild-type C. elegans and a mutant lacking pheromone signaling genes to identify both known and unknown ascarosides – in variable concentrations, these molecules can be both sex pheromones and developmental regulators.

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Researchers tie a variant in ADAMTS3 to breathing difficulties in dissimilar dog breeds, according to Discover's D-brief blog.

The Japan Times reports that researchers sequenced the genome of a woman who lived during the Jomon period.

Parents of children with rare genetic disease have to contend with shifts in the interpretation of genetic variants, the Wall Street Journal reports.

In Science this week: single-nucleus RNA sequencing of brain tissue from individuals with autism, and more.