This Week in PNAS

In the PNAS Early Edition this week, researchers at the University of Pennsylvania and their colleagues in China report their "reversal of pre-existing hyperglycemia" in streptozotocin-treated, diabetic mice via the "acute and temporally controlled excision of the Men1 gene, which encodes menin." In addition, the team shows than Men1 excision improved glucose metabolism and "upregulated a group of pro-proliferative genes in pancreatic islets," which they say supports the idea that "e

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.