This Week in PNAS

In the PNAS Early Edition this week, a team led by researchers at the University of Nebraska-Lincoln shows that "individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors." Namely, using quantitative pyrosequencing of the microbiota in 645 intercross line mice, the team found a core measurable microbiota of 64 taxonomic groups, within which they identified "co-segregation with 530 fully informative SNP markers" and "18 host quantitative trait loci that show significant or suggestive genome-wide linkage with re

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.