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In PNAS this week, researchers in New York, Massachusetts, and California collaborated to show how the polyamine pathway contributes to the pathogenesis of Parkinson's disease. The team started by using fMRI to identify regions of the brain stem resistant to the disease and then profiled gene expression levels from postmortem brain regions and identified a decrease in the catabolic polyamine enzyme spermidine/spermine N1-acetyltransferase 1, related to the disease.

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The UK and the European Union have come to a sticking point in the negotiation of how the UK might remain involved in the Horizon Europe research program, the Guardian reports.

The New York Times reports that experts pushed during a meeting of an FDA advisory board for the agency to require more safety data from SARS-CoV-2 vaccine trials.

The Washington Post reports Moderna expects that it will have enough data on its candidate SARS-CoV-2 vaccine to submit to regulatory authorities by mid-November.

In Science this week: ANXA11 variants affect calcium homeostasis and stress granule disassembly in ALS, and more.