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In the PNAS Early Edition this week, investigators in Japan show that miR-33, encoded by an intron of Srebp2, regulates HDL cholesterol in vivo. Using miR-33-deficient mice, the team found that "miR-33 repressed the expression of ATP-binding cassette transporter A1 protein, a key regulator of HDL synthesis, by mediating cholesterol efflux from cells to apolipoprotein A-I," they write.

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The US has sent its formal notice of withdrawal from the World Health Organization, according to the Wall Street Journal.

Science reports that a draft spending bill would increase the US National Institutes of Health budget by 13 percent.

The Harvard Crimson reports that Harvard and MIT are suing the Department of Homeland Security and ICE over the new international student visa policy.

In Nucleic Acids Research this week: algorithm to determine molecular sequence types and other microbial features, computational method to uncover R-loop structures, and more.