In the PNAS Early Edition this week, an international research team presents "an allele-specific copy number analysis of the in vivo breast cancer genome" and describe allele-specific copy number analysis of tumors — or ASCAT — a novel bioinformatics approach that allows users to "accurately dissect the allele-specific copy number of solid tumors, [while] simultaneously estimating and adjusting for both tumor ploidy and non-aberrant cell admixture." ASCAT profiles, the autho