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Afaf El-Sagheer and Tom Brown at the University of Southampton describe in this week's PNAS Early Edition a method for synthesizing chemically modified RNA constructs using click chemistry and solid-phase synthesis "to produce catalytically active hairpin ribozymes around 100 nucleotides in length." The authors suggest that "the ability to synthesize long RNA strands by a combination of solid-phase synthesis and click ligation is an important addition to RNA chemistry."

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