This Week in PNAS

Afaf El-Sagheer and Tom Brown at the University of Southampton describe in this week's PNAS Early Edition a method for synthesizing chemically modified RNA constructs using click chemistry and solid-phase synthesis "to produce catalytically active hairpin ribozymes around 100 nucleotides in length." The authors suggest that "the ability to synthesize long RNA strands by a combination of solid-phase synthesis and click ligation is an important addition to RNA chemistry."

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Researchers describe a way to share data while keeping it secure, Agence France Presse reports.

In Science this week: genetic mutations typically associated with esophageal cancer are common in older, healthy individuals, and more.

India's Council of Scientific and Industrial Research has a new director-general, according to ScienceInsider.

A new study links more than a hundred genes to autism spectrum disorder, Discover's D-brief blog reports.