This Week in PNAS

In the PNAS Early Edition this week, researchers at the University of Victoria and the National Institute of Allergy and Infectious Diseases report that they've inserted nine "essential genes" from Arctic bacteria into mammalian pathogenic bacteria "to construct stable, temperature-sensitive bacterial vaccines." One ligA gene, the team writes, "was shown to render Francisella tularensis, Salmonella enterica, and Mycobacterium smegmatis temperature-sensitive." Three tempe

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Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.

The New York Times reports that evidence linking trauma in one generation to epigenetic effects that influence subsequent generations may be overstated.

ScienceInsider reports that US National Institutes of Health researchers were told in the fall they could not obtain new human fetal tissue.

In PNAS this week: skin pigmentation evolution among KhoeSan, biomarkers for dengue virus progression, and more.